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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- TD3-H5145
- 製品名称
- Human TDP-43 Protein, His Tag
- タンパク質名
- TDP-43
- Species
- Human
- HOST
- E. coli
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE). |
| Endotoxin Level | N/A |
| Purity | 90% |
| Description | TDP-43, the transactive response (TAR)-DNA binding?Protein with a molecular weight of?43?KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/tdp-43-human-td3-h5145 |
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