リコンビナントタンパク質
ACROBiosystems社 プロダクトリスト:Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- TAI-H5253
- 製品名称
- Human TACI / TNFRSF13B (R119A, R122A) Protein, Fc Tag (MALS verified)
- タンパク質名
- TACI
- Species
- Human
- HOST
- HEK293
Overview
Synonyms | - |
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Characteristics | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin Level | 1.0 EU per μg |
Purity | 95% |
Description | Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B). It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells. |
Reference | - |
URL | https://www.acrobiosystems.com/P4085-Human-TACI--TNFRSF13B-%28R119A-R122A%29-Protein-Fc-Tag-%28MALS-verified%29.html |