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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- TA2-H55D3
- 製品名称
- Human TAP1 & TAP2?Full?Length Protein, Flag,His Tag&Flag,Twin-Strep Tag (Detergent)
- タンパク質名
- TAP1 & TAP2
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | Human TAP1 & TAP2?Full?Length Protein, Flag,His Tag&Flag,Twin-Strep Tag, produced by co-expression of TAP1 and TAP2, has a calculated MW of 84.9 kDa (TAP1) and 81.1 kDa (TAP2). Subunit TAP1 is fused with a flag tag at the N-terminus and a polyhistidine tag at the C-terminus, and subunit TAP2 contains a flag tag at the N-terminus and a twin strep tag at the C-terminus. The protein migrates as 55 kDa and 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE). |
| Endotoxin Level | N/A |
| Purity | 90% |
| Description | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/tap1-tap2-human-ta2-h55d3 |
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