SARS-CoV-2 Spike Trimer Protein (T19R, T95I, Y145H, EF156-157del, R158G, A222V, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified) [SPN-C52Hu]

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サプライヤー: AcroBioSystems
カタログNo.: SPN-C52Hu
製品名称: SARS-CoV-2 Spike Trimer Protein (T19R, T95I, Y145H, EF156-157del, R158G, A222V, L452R, T478K, D614G, P681R, D950N), His Tag (MALS verified)
タンパク質名: Spike protein
Species: SARS-CoV-2
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 137.8 kDa. The protein migrates as 160-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	SARS-CoV-2 Spike Trimer, His Tag (SPN-C52Hu) is the ectodomain of SARS-CoV-2 S protein which contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The mutations T19R, T95I, Y145H, EF156-157del, R158G, A222V, L452R, T478K, D614G, P681R, D950N were identified in the SARS-CoV-2 Delta Plus variant (Pango lineage: AY.4.2). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
Reference	-
URL	https://www.acrobiosystems.com/P4446-SARS-CoV-2-Spike-Trimer-Protein-%28T19R-T95I-Y145H-EF156-157del-R158G-A222V-L452R-T478K-D614G-P681R-D950N%29-His-Tag-%28MALS-verified%29.html

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