SARS-CoV-2?Spike Trimer Protein (K417N, D614G), His Tag (MALS verified) [SPN-C52Hm]

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サプライヤー: AcroBioSystems
カタログNo.: SPN-C52Hm
製品名称: SARS-CoV-2?Spike Trimer Protein (K417N, D614G), His Tag (MALS verified)
タンパク質名: Spike protein
Species: SARS-CoV-2
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 138.0 kDa. The protein migrates as 160-200 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	SARS-CoV-2 S protein (K417N,D614G), His Tag (SPN-C52Hm) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The mutations (K417N, D614G) were identified in the SARS-CoV-2 variant (known as B.1.351 or 20C/501Y.V2) which emerged in South Africa. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
Reference	-
URL	https://www.acrobiosystems.com/P4181-SARS-CoV-2%A0Spike-Trimer-Protein-%28K417N-D614G%29-His-Tag-%28MALS-verified%29.html

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