SARS-CoV-2 Spike Trimer Protein, His Tag (BA.2+L452M/Omicron) (MALS verified) [SPN-C5227]

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サプライヤー: AcroBioSystems
カタログNo.: SPN-C5227
製品名称: SARS-CoV-2 Spike Trimer Protein, His Tag (BA.2+L452M/Omicron) (MALS verified)
タンパク質名: Spike protein
Species: SARS-CoV-2
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 138.1 kDa. The protein migrates as 160-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	SARS-CoV-2 Spike Trimer, His Tag (BA.2+L452M/Omicron) (SPN-C5227) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1 (T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452M, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P)). The spike mutations are identified in multiple SARS-CoV-2 Omicron variants (Pango lineage: BA.2.9.1 and BA.2.13, GISAID clade: GRA). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
Reference	-
URL	https://www.acrobiosystems.com/P4941-SARS-CoV-2-Spike-Trimer-Protein-His-Tag-%28BA2L452MOmicron%29-%28MALS-verified%29.html

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