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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- SIR-H5255
- 製品名称
- Human SIGIRR Protein, Fc Tag (MALS verified)
- タンパク質名
- SIGIRR
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.0 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 95% |
| Description | Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/sigirr-human-sir-h5255 |
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