Human Siglec-7 / CD328 Protein, Fc (L118A, G120A, E201A) Tag, low Endotoxin (MALS verified) [SI7-H5257]

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サプライヤー: AcroBioSystems
カタログNo.: SI7-H5257
製品名称: Human Siglec-7 / CD328 Protein, Fc (L118A, G120A, E201A) Tag, low Endotoxin (MALS verified)
タンパク質名: Siglec-7
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a Fc (L118A, G120A, E201A) tag at the C-terminus. The protein has a calculated MW of 63.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L118A, G120A, E201A /EU number: L235A/G237A/E318A) in human immunoglobulin G1 (hIgG1) Fc strongly reduce binding of the Fc mutant to cell expressed FcγRs, resulting in an almost 4-fold reduction in ADCC compared to that of wild type human IgG1.
Endotoxin Level	0.01 EU per μg
Purity	95%
Description	Siglec-7 is a member of the human CD33‐related Siglec receptor. The extracellular region of Siglec‐7 is characterized by an N‐terminal V‐set Ig domain that can bind sialic acid and two C2‐set Ig domains. The cytoplasmic tail of Siglec‐7 has one immune‐receptor tyrosine‐based inhibitory motif (ITIM) and one ITIM‐like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/siglec-7-human-si7-h5257

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