Human Siglec-10 Protein, Mouse IgG2a Fc Tag, low endotoxin [SI0-H525b]

Synonyms	-
Characteristics	This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 85.6 kDa. The protein migrates as 90-120 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	0.1 EU per μg
Purity	95%
Description	The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Reference	-
URL	https://www.acrobiosystems.com/P2593-Human-Siglec-10-Protein-Mouse-IgG2a-Fc-Tag-low-endotoxin.html

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