Human SDF-1 / CXCL12 Protein, Research Grade [SD1-H5116]

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Synonyms	-
Characteristics	This protein carries no "tag". The protein has a calculated MW of 8.1 kDa. The protein migrates as 10 kDa±3 kDa under reducing (R) condition, and 15 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE)
Endotoxin Level	0.01 EU per μg
Purity	95%
Description	Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells
Reference	-
URL	https://www.acrobiosystems.com/products/protein/sdf-1-human-sd1-h5116

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