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- サプライヤー
- AcroBioSystems
- カタログNo.
- PT3-H5143
- 製品名称
- Human PTP4A3 Protein, His Tag (MALS verified)
- タンパク質名
- PTP4A3
- Species
- Human
- HOST
- E. coli
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 21.1 kDa. The protein migrates as 23-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE). |
| Endotoxin Level | N/A |
| Purity | 90% |
| Description | ??PTP4A3 (Protein Tyrosine Phosphatase 4A3)?? is an oncogenic phosphatase that promotes tumor metastasis by enhancing cell migration, invasion, and survival. It is overexpressed in multiple cancers (e.g., breast, ovarian, colorectal) and correlates with poor prognosis. PTP4A3 activates Rho GTPases and downstream pathways (ROCK/LIMK/cofilin) to remodel the actin cytoskeleton, facilitating cancer cell dissemination. Its dual cysteine-based catalytic domain dephosphorylates key signaling proteins, driving aggressive phenotypes. Targeting PTP4A3 offers therapeutic potential for inhibiting metastasis. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/ptp4a3-human-pt3-h5143 |
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