Human PLAU / uPA Protein, His Tag [PLU-H5229]

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Synonyms	-
Characteristics	Human PLAU, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 47.2 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.<br> <strong>Please note that the protein is not activated by protease digestion. In vitro activation is generally recommended for higher activity.</strong>
Endotoxin Level	1.0 EU per μg
Purity	92%
Description	Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys ? Pro ? Gly - Arg560 - Val561 ? Val ? Gly ? Gly ? Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
Reference	-
URL	https://www.acrobiosystems.com/products/protein/plau-human-plu-h5229

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