Human PLAU / uPA Protein, His Tag (activated by trypsin) (active enzyme) [PLU-H5228]

サプライヤー: AcroBioSystems
カタログNo.: PLU-H5228
製品名称: Human PLAU / uPA Protein, His Tag (activated by trypsin) (active enzyme)
タンパク質名: PLAU
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The active form of Human PLAU is a disulfide-linked heterodimer composed of long chain A (Ser 21 - Phe 177) and chain B (Ile 179 - Leu 431) with calculated MW of 17.8 kDa and 29.2 kDa. The long chain A is further cleaved to yield a short chain A (Lys 156 - Phe 177) and N-terminal fragment (Ser 21 - Lys 155) with calculated MW of 15.3 kDa. The protein migrates as 17 kDa (N-terminal fragment), 32-35 kDa (chain B) and 45-50 kDa (long chain A & chain B) under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys ? Pro ? Gly - Arg560 - Val561 ? Val ? Gly ? Gly ? Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
Reference	-
URL	https://www.acrobiosystems.com/P2936-Human-PLAU--uPA-Protein-His-Tag-%28activated-by-trypsin%29-%28active-enzyme%29.html

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