Human Perlecan Protein, His Tag, low endotoxin [PEN-H5245]

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 12.2 kDa. The protein migrates as 11-12 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Endotoxin Level	0.01 EU per μg
Purity	90%
Description	Siglec-15 is a transmembrane glycoprotein belonging to the Siglec family, recognized for its sialic acid-binding properties and role in immune regulation. Structurally, its extracellular domain contains two Ig-like domains, and it functionally associates with the signaling adaptors DAP12 and DAP10. Siglec-15 is expressed on immune cells, including osteoclasts, macrophages, and dendritic cells. It exerts its function by binding to its ligand, the sialyl-Tn antigen. This interaction is critical for inducing TGF-beta production by tumor-associated macrophages and plays an essential role in osteoclast formation and TRANCE/RANK Ligand signaling.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/perlecan-human-pen-h5245

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