Human Parkin Protein, His Tag [PAN-H5543] | ナミキ商事株式会社

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 53.5 kDa. The protein migrates as 55-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	85%
Description	Parkin is an E3 ubiquitin ligase encoded by the PARK2 gene, comprising 465 amino acids and containing an N?terminal ubiquitin?like domain and C?terminal RING domains. It plays a pivotal role in the ubiquitin?proteasome system, tagging damaged or misfolded proteins for degradation. Parkin is essential for mitophagy, the selective clearance of dysfunctional mitochondria, thereby maintaining cellular homeostasis. Mutations in PARK2 cause autosomal recessive juvenile Parkinson’s disease, leading to dopaminergic neuron loss. Beyond neuroprotection, Parkin influences apoptosis regulation and cellular stress responses. Its dysfunction is linked to mitochondrial impairment, protein aggregation, and neurodegeneration, making it a key target in Parkinson’s disease research
Reference	-
URL	https://www.acrobiosystems.com/products/protein/parkin-human-pan-h5543

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