Synonyms |
- |
Characteristics |
This?protein?carries?a?polyhistidine?tag?at?the?C-terminus. This?protein?contains?a?furin?cleavage?site,?251-RHKR-254,?and?is?partially?processed?into?N?and?C-terminal?fragment?with?calculated?MW?of?17.1 kDa?and?19.7 kDa?respectively. The?protein?migrates?as?23-25?kDa (C-terminus)?and?46-73?kDa (full?length)?under?reducing?(R)?condition?(SDS-PAGE)?due?to?glycosylation. |
Endotoxin Level |
1.0 EU per μg |
Purity |
90% |
Description |
Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool. |
Reference |
- |
URL |
https://www.acrobiosystems.com/P3343-MERS-Nucleocapsid-protein-His-Tag.html |