Biotinylated Human Mucin-1 (890-1158) Protein, His,Avitag? [MU1-H82E5]

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain. Each partial α and partial β chain has a calculated MW of 21.3 kDa (partial α chain) and 10.2 kDa (partial β chain).The protein migrates as 45-70 kDa (partial α and partial β chain, glycosylated), 7 kDa (speculated as partial β chain, nonglycosylated) and 14-15 kDa (partial β chain, glycosylated) under reducing (R) condition (SDS-PAGE).
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
Reference	-
URL	https://www.acrobiosystems.com/P2986-Biotinylated-Human-Mucin-1-%28890-1158%29-Protein-HisAvitag%E2%84%A2.html

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