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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
MSN-H82E9
製品名称
Biotinylated Human Mesothelin / MSLN (296-580), His Tag & Avi Tag (Avitag)
タンパク質名
Mesothelin
Species
Human
HOST
HEK293
25ug: 74,000円
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200ug: 290,000円
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Overview

Synonyms MSLN,Mesothelin,MPF
Characteristics This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 35.9 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >95% as determined by SDS-PAGE.
Description Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Reference (1) Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140.
(2) Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808.
(3) Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198.
(4) Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
URL http://www.acrobiosystems.com/P2372-Biotinylated-Human-Mesothelin--MSLN-Protein-His-Tag-Avi-Tag.html

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