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- サプライヤー
- AcroBioSystems
- カタログNo.
- MM7-C53H3
- 製品名称
- Cynomolgus MMP-7 Protein, His Tag (active enzyme, HPLC verified)
- タンパク質名
- MMP-7
- Species
- Cynomolgus
- HOST
- CHO
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.9 kDa. The protein migrates as 30-32 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | MMP-7 (matrilysin), the smallest zinc-dependent endopeptidase in the MMP family, lacks a hemopexin domain but features a catalytic zinc-binding motif (HEXXHXXGXXH) critical for degrading extracellular matrix (ECM) components, including collagens III/IV/V, elastin, and proteoglycans. Activated via proteolytic cleavage (e.g., by MMP-3), it promotes tissue remodeling in wound healing while driving pathological processes such as tumor invasion (via E-cadherin degradation and Wnt/β-catenin activation) and fibrosis (via β-catenin-mediated renal damage). Overexpressed in epithelial cancers, MMP-7 correlates with metastasis but paradoxically shows protective genetic variants in some contexts. It also processes non-ECM substrates like TNF-α and Fas ligand, amplifying inflammation and oncogenesis. In fibrotic diseases, elevated serum MMP-7 predicts progression, serving as a diagnostic biomarker. Therapeutic strategies targeting MMP-7, including inhibitors and monoclonal antibodies, highlight its dual roles as both a driver of ECM disruption and a modulator of immune-tumor interactions. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/mmp-7-cynomolgus-mm7-c53h3 |
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