タンパク質、抗体、アッセイキット
タンパク質カタログ
- サプライヤー
- AcroBioSystems
- カタログNo.
- MCM-R52H4
- 製品名称
- Rat MCAM / CD146 Protein, His Tag
- タンパク質名
- MCAM
- Species
- Rat
- HOST
- HEK293
Overview
Synonyms | - |
---|---|
Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 61.2 kDa. The protein migrates as 70-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin Level | 1.0 EU per μg |
Purity | 95% |
Description | CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition. |
Reference | - |
URL | https://www.acrobiosystems.com/P4035-Rat-MCAM--CD146-Protein-His-Tag.html |