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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- LY5-M52H5
- 製品名称
- Mouse LY75 / CD205 Protein, His Tag (MALS verified)
- タンパク質名
- LY75
- Species
- Mouse
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 190.0 kDa. The protein migrates as 230-260 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | lymphocyte antigen 75 (Ly 75, also known as CD205, CLEC13B, GP200-MR6 and DEC-205, is a type I transmembrane protein that is primarily expressed on dendritic cells and thymic epithelial cells. LY75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has shown strong preclinical anti-tumor activity in lymphoma. After being verified as a single drug in vivo, the antibody-drug conjugate has a synergistic effect with the BCL2 inhibitor Venetoclax and the anti-cd20 monoclonal antibody rituximab. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/ly75-mouse-ly5-m52h5 |
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