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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- LR6-H5253
- 製品名称
- Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag
- タンパク質名
- LRP-6
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 95.8 kDa. The protein migrates as 55 kDa and 110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 0.1 EU per μg |
| Purity | 90% |
| Description | LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/lrp-6-human-lr6-h5253 |
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