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タンパク質(癌免疫療法用)

ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
LR2-H5256
製品名称
Human LRRC32 / GARP / Garpin Protein, Fc Tag
タンパク質名
LRRC32
Species
Human
HOST
HEK293
100ug: 87,000円
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Overview

Synonyms GARP,Garpin,D11S833E
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.6 kDa. The protein migrates as 35 kDa and 100-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >95% as determined by SDS-PAGE.
Description Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of na?ve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress na?ve T cell proliferation.
Reference (1) Battaglia, M., et al., 2009, Eur. J. Immunol. 39(12): 3296-3300.
(2) Wang, R. et al. 2008, PloS ONE 3(7): e2705.
(3) Probst-Kepper, M. et al. 2009, J. Cell. Mol. Med. 13(9B): 3343-3357.
URL http://www.acrobiosystems.com/P2371-Human-LRRC32--GARP--Garpin--D11S833E-Protein-Fc-Tag.html

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