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- サプライヤー
- AcroBioSystems
- カタログNo.
- LR2-H5256
- 製品名称
- Human LRRC32 / GARP / Garpin Protein, Fc Tag
- タンパク質名
- LRRC32
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.4 kDa. The protein migrates as 105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 95% |
| Description | Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of na?ve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress na?ve T cell proliferation. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/lrrc32-human-lr2-h5256 |
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