Human Laminin 221 Protein, premium grade [LA2-H5269]

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Synonyms	-
Characteristics	Human Laminin 221 Protein, premium grade, produced by co-expression of Laminin alpha2E8, Laminin beta2E8 and Laminin gamma1E8, has a calculated MW of 94.3 kDa, 51.3 kDa and 53.7 kDa. The non-reducing (NR) protein migrates as 118-133 kDa due to glycosylation.
Endotoxin Level	0.01 EU per μg
Purity	90%
Description	Laminin-221 (LM221) takes multiple roles as a scaffold to store cells, growth factors and cytokines and is the most likely expressed cardiac laminin that maintains physiological activities of myocytes. Laminin 221-E8 consists of the C-terminal end of the alpha 2, beta 2, and gamma 1 chains. Previous study has confirmed that the laminin-221 heterotrimer (α2β2γ1) could bind integrin α7X1 and α7X2. Latest research indicated that the administration of LM221 enhanced accumulation of smooth muscle actin (SMA) and isolectin B4 (ILB4) double-positive cells to the damaged area and contributed to the improvement of cardiac function.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/laminin-221-human-la2-h5269

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