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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- LA1-C52A3
- 製品名称
- Rhesus macaque LAIR-1 / CD305 Protein, Mouse IgG2a Fc Tag
- タンパク質名
- LAIR-1
- Species
- Rhesus macaque
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 95% |
| Description | Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell?mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/lair-1-rhesus-macaque-la1-c52a3 |
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