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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- KL1-H5249
- 製品名称
- Human KLRG1 Protein, His Tag
- タンパク質名
- KLRG1
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 17.4 kDa. The protein migrates as 30-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/klrg1-human-kl1-h5249 |
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