Biotinylated Cynomolgus KLRG1 Protein, His,Avitag? [KL1-C82Q4]

Synonyms	-
Characteristics	This protein carries an Avi tag (Avitag?) at the N-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 18.5 kDa. The protein migrates as 22-25 kDa and 26-31 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is specifically expressed on NK cells and activated CD8+ T-cells and has been postulated to be a marker of senescence. KLRG1+ T cells are a major reason of chronic tissue damage in some autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In tumors, tumor cells which express E-cadherin or N-cadherin bind to KLRG1 and inhibit the antitumor activity of T and NK cells. Thus, KLRG1 acts as an immunocheckpoint inhibitory receptor.
Reference	-
URL	https://www.acrobiosystems.com/P7434-Biotinylated-Cynomolgus-KLRG1-Protein-HisAvitag%E2%84%A2.html

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