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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- KI4-H5255
- 製品名称
- Human KIR2DL4 / CD158d Protein, Fc Tag
- タンパク質名
- KIR2DL4
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the?immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/kir2dl4-human-ki4-h5255 |
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