Human KIR2DL4 / CD158d Protein, Fc Tag [KI4-H5255]

Synonyms	-
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the?immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.
Reference	-
URL	https://www.acrobiosystems.com/P4683-Human-KIR2DL4--CD158d-Protein-Fc-Tag.html

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