| Synonyms |
- |
| Characteristics |
Rat ITGAV&ITGB6 Heterodimer, His Tag&Tag Free, has a calculated MW of 112.3 kDa (ITGAV) & 80.1 kDa (ITGB6). The protein migrates as 70-85 kDa and 125-145 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level |
1.0 EU per μg |
| Purity |
90% |
| Description |
Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency?associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1. |
| Reference |
- |
| URL |
https://www.acrobiosystems.com/P5572-Rat-Integrin-alpha-V-beta-6-%28ITGAVITGB6%29-Heterodimer-Protein-His-TagTag-Free-%28MALS-verified%29.html |
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