Biotinylated Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag?&Tag Free (MALS verified) [IT6-M82W9]

サプライヤー: AcroBioSystems
カタログNo.: IT6-M82W9
製品名称: Biotinylated Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag?&Tag Free (MALS verified)
タンパク質名: Integrin alpha V beta 6
Species: Mouse
HOST: HEK293

Synonyms	-
Characteristics	Biotinylated Mouse ITGAV&ITGB6 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 80.2 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB6 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa and 135-150 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency?associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
Reference	-
URL	https://www.acrobiosystems.com/P5305-Biotinylated-Mouse-Integrin-alpha-V-beta-6-%28ITGAVITGB6%29-Heterodimer-Protein-HisAvitag%E2%84%A2Tag-Free-%28MALS-verified%29.html

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