Biotinylated Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag?&Tag Free [IT6-C82E3]

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サプライヤー: AcroBioSystems
カタログNo.: IT6-C82E3
製品名称: Biotinylated Cynomolgus Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His,Avitag?&Tag Free
タンパク質名: Integrin alpha V beta 6
Species: Cynomolgus
HOST: HEK293

Synonyms	-
Characteristics	Biotinylated Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 114.8 kDa (ITGAV) & 79.9 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag?) and subunit ITGB6 contains no tag but a basic tail at the C-terminus. The protein migrates as 130-150 kDa (ITGAV) and 80-95 kDa (ITGB6) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	90%
Description	Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency?associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/integrin-alpha-v-beta-6-cynomolgus-it6-c82e3

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