Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His,Avitag?&Tag Free [IT3-H82W9]

サプライヤー: AcroBioSystems
カタログNo.: IT3-H82W9
製品名称: Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein, His,Avitag?&Tag Free
タンパク質名: Integrin alpha V beta 3
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	Biotinylated Human ITGAV&ITGB3 Heterodimer Protein, His, Avitag?&Tag Free, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 114.6 kDa (ITGAV) and 81.8 kDa (ITGB3). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag?) and subunit ITGB3 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 31 (ITGAV) & Gly 27 (ITGB3). The non-reducing (NR) protein migrates as 135 kDa (ITGAV) & 80 kDa (ITGB3) respectively due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Reference	-
URL	https://www.acrobiosystems.com/P4645-Biotinylated-Human-Integrin-alpha-V-beta-3-%28ITGAVITGB3%29-Heterodimer-Protein-HisAvitag%E2%84%A2Tag-Free.html

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