Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free [IT3-H52W8]

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サプライヤー: AcroBioSystems
カタログNo.: IT3-H52W8
製品名称: Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free
タンパク質名: Integrin alpha 2b beta 3
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	Human ITGAIIb&ITGB3 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAIIb and ITGB3, has a calculated MW of 111.4 kDa (ITGAIIb) and 81.8 kDa (ITGB3). Subunit ITGAIIb is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB3 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 125-130 kDa (ITGAIIb) and 90-95 kDa (ITGB3) when calibrated against Star Ribbon Pre-stained Protein Marker respectively due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces inside-out signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outside-in signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal antibodies.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/integrin-alpha-2b-beta-3-human-it3-h52w8

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