Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer Protein, His Tag&Tag Free (MALS verified) [IT2-C52E2]

サプライヤー: AcroBioSystems
カタログNo.: IT2-C52E2
製品名称: Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer Protein, His Tag&Tag Free (MALS verified)
タンパク質名: Integrin alpha M beta 2
Species: Canine
HOST: HEK293

Synonyms	-
Characteristics	Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer, His Tag&Tag Free. The protein has a calculated MW of 128 kDa \| 80 kDa. The protein migrates as 80-90 kda and 155-175 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
Reference	-
URL	https://www.acrobiosystems.com/P5449-Canine-Integrin-alpha-M-beta-2-%28ITGAMITGB2%29-Heterodimer-Protein-His-TagTag-Free-%28MALS-verified%29.html

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