検索リコンビナントタンパク質
ACROBiosystems社 プロダクトリスト：Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- IT1-H52W8
- 製品名称
- Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free
- タンパク質名
- Integrin isoform alpha-7X2B beta 1
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.5 kDa (ITGA7X2B) and 83.7 kDa (ITGB1). Subunit ITGA7X2B is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 130-135 kDa (ITGA7X2B) and 100-125 kDa (ITGB1) respectively due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3. |
| Reference | - |
| URL | https://www.acrobiosystems.com/P2369-Human-Integrin-isoform-alpha-7X2B-beta-1-%28ITGA7X2BITGB1%29-Heterodimer-Protein-His-TagTag-Free.html |
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