ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein
- Integrin alpha 6 beta 1
|Synonyms||Integrin alpha 6 beta 1,ITGA6B1,ITGA6&ITGB1,CD49f,VLA-6|
|Characteristics||Human ITGA6 & ITGB1 Heterodimer Protein, produced by co-expression of ITGA6 and ITGB1, has a calculated MW of 116.8 kDa (ITGA6) and 83.7 kDa (ITGB1). Subunit ITGA6 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 24 (ITGA6) & Gln 21 (ITGB1). As a result of glycosylation, the protein migrates as 120-130 kDa under reducing (R) condition, and 100-125 kDa and 130-150 kDa under non-reducing (NR) condition (SDS-PAGE).|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>90% as determined by SDS-PAGE.|
|Description||Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. ITGA6 has been shown to interact with TSPAN4 and GIPC1.|
|Reference||(1) Tachibana I, et al., 1997, The Journal of Biological Chemistry, 272 (46): 29181-29189.
(2) Tani TT, et al., 2001, The Journal of Biological Chemistry, 276 (39): 36535-36542.
(3) Lipscomb EA, etal., 2005, Cancer Metastasis Reviews, 24 (3): 413-423.