Human Insulin R / CD220 (28-944) Protein, His Tag (MALS & SPR verified) [INR-H52Ha]

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サプライヤー: AcroBioSystems
カタログNo.: INR-H52Ha
製品名称: Human Insulin R / CD220 (28-944) Protein, His Tag (MALS & SPR verified)
タンパク質名: Insulin R
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The mature form of Insulin R a disulfide-linked heterotetramer?composed of?2?alpha?and?2?beta chains. Each α and β chain (partial fragment) has a calculated MW of?83.6 kDa and 22.8 kDa. The protein migrates as 120-130 kDa and 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/insulin-r-human-inr-h52ha

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