Human Integrin alpha 6 beta 4 (ITGA6&ITGB4) Heterodimer Protein, His Tag&Tag Free (MALS verified) [IN4-H52W3]

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サプライヤー: AcroBioSystems
カタログNo.: IN4-H52W3
製品名称: Human Integrin alpha 6 beta 4 (ITGA6&ITGB4) Heterodimer Protein, His Tag&Tag Free (MALS verified)
タンパク質名: Integrin alpha 6 beta 4
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	Human ITGA6&ITGB4 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA6 and ITGB4, has a calculated MW of 116.8 kDa (ITGA6) and 81.8 kDa (ITGB4). Subunit ITGA6 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB4 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 130-140 kDa (ITGA6) and 75-85 kDa (ITGB4) when calibrated against Star Ribbon Pre-stained Protein Marker respectively due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Human integrin alpha(10)I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha(10)I did recognize collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/integrin-alpha-6-beta-4-human-in4-h52w3

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