Rabbit IL-4 R alpha / CD124 Protein, His Tag (MALS & SPR verified) [ILR-R52H8]

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.7 kDa. The protein migrates as 40-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL?13Ra1 to form the type II receptor, which is responsive to both IL?4 and IL?13. Interleukin-4 receptor has been shown to interact with SHC1.
Reference	2974
URL	https://www.acrobiosystems.com/products/protein/il-4-r-alpha-rabbit-ilr-r52h8

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