Rat IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag (SPR verified) [ILR-R52H5]

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サプライヤー: AcroBioSystems
カタログNo.: ILR-R52H5
製品名称: Rat IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag (SPR verified)
タンパク質名: IL-4 R alpha & IL-13 R alpha 1
Species: Rat
HOST: HEK293

Synonyms	-
Characteristics	Rat IL-4 R alpha & IL-13 R alpha 1 Protein, His Tag&His Tag, produced by co-expression of IL-4 R alpha and IL-13 R alpha 1, has a calculated MW of 29.1 kDa (IL-4 R alpha) and 41 kDa (IL-13 R alpha 1). Subunit IL-4 R alpha is fused with a polyhistidine tag at the C-terminus, and subunit IL-13 R alpha 1 contains a polyhistidine tag at the C-terminus. The protein migrates as 43-53 kDa and 60-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	90%
Description	Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL?13Ra1 to form the type II receptor which is responsive to both IL?4 and IL?13. Interleukin-4 receptor has been shown to interact with SHC1.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/il-4-r-alpha-il-13-r-alpha-1-rat-ilr-r52h5

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