Human IL-31 RA & OSMR Protein, Fc Tag (MALS verified) [ILR-H525e]

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Synonyms	-
Characteristics	Human IL-31 RA & OSMR Protein, Fc Tag, produced by co-expression of IL-31 RA and OSMR, has a calculated MW of 165.7 kDa. This protein carries a human IgG1 Fc tag at the C-terminus. The protein migrates as 200-250 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMR beta but also in a homomeric receptor complex.
Reference	2935
URL	https://www.acrobiosystems.com/products/protein/il-31-ra-osmr-human-ilr-h525e

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