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- サプライヤー
- AcroBioSystems
- カタログNo.
- ILR-C82E3
- 製品名称
- Biotinylated Cynomolgus IL-4 R alpha / CD124 Protein, His,Avitag? (MALS verified)
- タンパク質名
- IL-4 R alpha
- Species
- Cynomolgus
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 27.3 kDa. The protein migrates as 40-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | N/A |
| Purity | 95% |
| Description | IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin?4?Receptor (IL4R) also known as CD124, IL4Rα and?BSF?receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R?can?alternatively?associate?with?IL?13Ra1?to?form?the?type?II?receptor?which?is?responsive?to?both?IL?4?and?IL?13. Interleukin-4 receptor has been shown to interact with SHC1. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/il-4-r-alpha-cynomolgus-ilr-c82e3 |
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