ナミキ商事株式会社 医薬品及び創薬化学品の専門商社

医薬品及び創薬化学品の専門商社

検索検索

バイオ製品Bio Products

リコンビナントタンパク質

ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
ILR-C5258
製品名称
Cynomolgus / Rhesus macaque IL-4 R alpha / CD124 Protein, Fc Tag
タンパク質名
IL-4 R alpha
Species
Cynomolgus / Rhesus macaque
HOST
HEK293
1mg: 554400円
お問い合わせ
50ug: 78400円
お問い合わせ

Overview

Synonyms -
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level 1.0 EU per μg
Purity 95%
Description IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).
Interleukin?4?Receptor (IL4R) also known as CD124, IL4Rα and?BSF?receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R?can?alternatively?associate?with?IL?13Ra1?to?form?the?type?II?receptor?which?is?responsive?to?both?IL?4?and?IL?13. Interleukin-4 receptor has been shown to interact with SHC1.
Reference -
URL https://www.acrobiosystems.com/P1743-Cynomolgus--Rhesus-macaque-IL-4-R-alpha--CD124-Protein-Fc-Tag.html

お問い合わせリスト(-)

お問い合わせフォーム