検索リコンビナントタンパク質
ACROBiosystems社 プロダクトリスト：Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- ILC-H5257
- 製品名称
- Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
- タンパク質名
- IL-17 RA & IL-17 RC
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | Human IL17RA & IL17RC Protein, Fc Tag&Fc Tag is produced by co-expression of IL-17RA and IL-17RC, has a calculated MW of 60.0 kDa (IL-17RA) & 75.7 kDa (IL-17RC). Subunit IL-17RA is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-17RC is fused with a human IgG1 Fc tag at the C-terminus. The reducing (R) heterodimer protein migrates as 80-90 kDa and 100-110 kDa due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 95% |
| Description | Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. |
| Reference | - |
| URL | https://www.acrobiosystems.com/P3427-Human-IL-17-RAIL-17-RC-Heterodimer-Protein-Fc-TagFc-Tag-%28MALS-verified%29.html |
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