Biotinylated Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, His,Avitag?&Tag Free (MALS verified) [ILB-M82W3]

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サプライヤー: AcroBioSystems
カタログNo.: ILB-M82W3
製品名称: Biotinylated Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, His,Avitag?&Tag Free (MALS verified)
タンパク質名: IL23A & IL12B
Species: Mouse
HOST: HEK293

Synonyms	-
Characteristics	Biotinylated Mouse IL23A & IL12B Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of IL23A and IL12B, has a calculated MW of 23.2 kDa (IL23A) and 35.8 kDa (IL12B). Subunit IL23A is fused with a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?) and subunit IL12B contains no tag at the C-terminus. The protein migrates as 27 kDa, 42 kDa and 43-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	90%
Description	Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Reference	-
URL	N/A

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