Human IL-23 alpha&Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free, Ultra Low Endotoxin (MALS verified) [ILB-HR52W4]

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サプライヤー: AcroBioSystems
カタログNo.: ILB-HR52W4
製品名称: Human IL-23 alpha&Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free, Ultra Low Endotoxin (MALS verified)
タンパク質名: IL23A & IL12B
Species: Human & Rat
HOST: HEK293

Synonyms	-
Characteristics	Human IL-23A&Rat IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL23A and IL12B, has a calculated MW of 20.6 kDa (IL23A) and 35.9 kDa (IL12B). Subunit IL-23A is fused with a polyhistidine tag at the N-terminus and subunit IL-12B contains no tag. The protein migrates as 23-25 kDa,43 kDa and 45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	0.0005 EU per μg
Purity	90%
Description	Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/il23a-il12b-human-rat-ilb-hr52w4

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