Biotinylated Human IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag?&Tag Free (MALS verified) [ILB-H82W6]

サプライヤー: AcroBioSystems
カタログNo.: ILB-H82W6
製品名称: Biotinylated Human IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag?&Tag Free (MALS verified)
タンパク質名: IL23A & IL12B
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of IL23A and IL12B, has a calculated MW of 21.9 kDa (IL23A) & 34.7 kDa (IL12B). Subunit IL23A is fused with an Avi tag (Avitag?), followed by a polyhistidine tag at the N-terminus and subunit IL12B contains no tag. The predicted N-terminus is His (IL23A) & Ile 23 (IL12B). The reducing (R) protein migrates as 26 kDa (IL23A) & 40-45 kDa (IL12B) respectively due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Reference	-
URL	https://www.acrobiosystems.com/P2217-Biotinylated-Human-IL-23-alphaIL-12-beta-Heterodimer-Protein-HisAvitag%E2%84%A2Tag-Free-%28MALS-verified%29.html

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