リコンビナントタンパク質
ACROBiosystems社 プロダクトリスト:Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- ILB-H82F1
- 製品名称
- Biotinylated Human IL-17B Protein, Fc,Avitag? (MALS verified)
- タンパク質名
- IL-17B
- Species
- Human
- HOST
- HEK293
Overview
Synonyms | - |
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Characteristics | This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 45.8 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin Level | 1.0 EU per μg |
Purity | 95% |
Description | IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA? IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells. |
Reference | - |
URL | https://www.acrobiosystems.com/P5490-Biotinylated-Human-IL-17B-Protein-FcAvitag%E2%84%A2-%28MALS-verified%29.html |