Biotinylated Human IL-12?R?beta?2 Protein, His,Avitag? (MALS verified) [ILB-H82E4]

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サプライヤー: AcroBioSystems
カタログNo.: ILB-H82E4
製品名称: Biotinylated Human IL-12?R?beta?2 Protein, His,Avitag? (MALS verified)
タンパク質名: IL-12 R beta 2
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 71.1 kDa. The protein migrates as 90-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	90%
Description	The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12RB2 is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL-12B2 gene acts as tumor suppressor in human acute and chronic B-cell leukemias/lymphomas， IL-12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/il-12-r-beta-2-human-ilb-h82e4

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