リコンビナントタンパク質
ACROBiosystems社 プロダクトリスト:Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- ILB-H52H6
- 製品名称
- Human IL-12?R?beta?2 Protein, His Tag (MALS verified)
- タンパク質名
- IL-12 R beta 2
- Species
- Human
- HOST
- HEK293
Overview
Synonyms | - |
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Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.0 kDa. The protein migrates as 85-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin Level | 1.0 EU per μg |
Purity | 95% |
Description | The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12RB2 is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL-12B2 gene acts as tumor suppressor in human acute and chronic B-cell leukemias/lymphomas, IL-12R beta 2 directly restrains multiple myeloma cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy. |
Reference | - |
URL | https://www.acrobiosystems.com/P5942-Human-IL-12%A0R%A0beta%A02-Protein-His-Tag-%28MALS-verified%29.html |